Comparison of the performance of 6 prognostic signatures for estrogen receptor–positive breast cancer: a secondary analysis of a randomized clinical trial
Importance Multiple molecular signatures are available for managing estrogen receptor (ER)–
positive breast cancer but with little direct comparative information to guide the patient's
choice. Objective To conduct a within-patient comparison of the prognostic value of 6
multigene signatures in women with early ER-positive breast cancer who received
endocrine therapy for 5 years. Design, Setting, and Participants This retrospective biomarker
analysis included 774 postmenopausal women with ER-positiveERBB2 (formerlyHER2) …
positive breast cancer but with little direct comparative information to guide the patient's
choice. Objective To conduct a within-patient comparison of the prognostic value of 6
multigene signatures in women with early ER-positive breast cancer who received
endocrine therapy for 5 years. Design, Setting, and Participants This retrospective biomarker
analysis included 774 postmenopausal women with ER-positiveERBB2 (formerlyHER2) …
