[HTML][HTML] Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4–dependent manner
X Min, H Cheng, X Cao, Z Chen, X Zhang, Y Li… - Cell Stress and …, 2022 - Elsevier
Metastasis is responsible for most of the hepatocellular carcinoma (HCC)–associated death.
However, its underlying mechanism has yet to be fully elucidated. Glycolysis-derived lactate
has been shown to be a powerful regulator of cancer metastasis. Heat shock protein A12A
(HSPA12A) encodes a novel member of HSP70 family. We have recently demonstrated that
heat shock protein A12A (HSPA12A) inhibited renal cancer cell migration by suppressing
lactate output and glycolytic activity, which were mediated by unstabilizing CD147 and …
However, its underlying mechanism has yet to be fully elucidated. Glycolysis-derived lactate
has been shown to be a powerful regulator of cancer metastasis. Heat shock protein A12A
(HSPA12A) encodes a novel member of HSP70 family. We have recently demonstrated that
heat shock protein A12A (HSPA12A) inhibited renal cancer cell migration by suppressing
lactate output and glycolytic activity, which were mediated by unstabilizing CD147 and …
